Inhibition of insulin signaling by protein kinase C
نویسندگان
چکیده
Background: Insulin actions are decreased in endothelial cells causing vascular dysfunction in diabetic and insulin resistant states. Results: IRS2 and p85 subunit of PI3Kinase are targets of PKC and angiotensin activation inhibiting insulin signaling. Conclusion: PKC and angiotensin activation inhibit selective insulin activation of Akt/eNOS in endothelial cells. Significance: We provide a biochemical mechanism by which PKC activation inhibits insulin signaling and protective actions in endothelial cells.
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تاریخ انتشار 2011